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BioLiP

Structure of PDB 4wtm Chain A Binding Site BS01

Receptor Information
>4wtm Chain A (length=553) Species: 356411 (Hepatitis C virus JFH-1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSMSYSWTGALITPCGPEEEKLPINPLSNSLLRYHNKVYCTTSKSASQRA
KKVTFDRTQVLDAHYDSVLKDIKLAASKVSARLLTLQQACQLTPPHSARS
KYGFGAKEVRSLSGRAVNHIKSVWKDLLEDPQTPIPTTIMAKNEVFCVDP
AKGGKKPARLIVYPDLGVRVCEKMALYDITQKLPQAVMGASYGFQYSPAQ
RVEYLLKAWAEKKDPMGFSYDTRHFDSTVTERDIRTEESIYQACSLPEEA
RTAIHSLTERLYVGGPMFNSKGQTCGYRRCRASGVLTTSMGNTITCYVKA
LAACKAAGIVAPTMLVCGDDLIVISESQGTEEDERNLRAFTEAMTRYSAP
PGDPPRPEYDLELITSCSSNVSVALGPRGRRRYYLTRDPTTPLARAAWET
VRHSPINSWLGNIIQYAPTIWVRMVLMTHFFSILMVQDTLDQNLNFEMYG
SVYSVNPLDLPAIIERLHGLDAFSMHTYSHHELTRVASALRKLGAPPLRV
WKSRARAVRASLISRGGKAAVCGRYLFNWAVKTKLKLTPLPEARLLDLSS
WFT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4wtm Structural basis for RNA replication by the hepatitis C virus polymerase.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		S96 A97 K141 I160 Y162 R168 K172 G283 L285 S288 Y448 G449
Binding residue
(residue number reindexed from 1)		S97 A98 K142 I161 Y163 R169 K173 G284 L286 S289 Y449 G450
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4wtm, PDBe:4wtm, PDBj:4wtm
PDBsum4wtm
PubMed25678663
UniProtQ99IB8|POLG_HCVJF Genome polyprotein

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