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BioLiP

Structure of PDB 2h51 Chain A Binding Site BS01

Receptor Information
>2h51 Chain A (length=167) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSEGNVKLCSLEEAQRIWSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDST
FLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI
IIQACKGDSPGVVWFKD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2h51 An allosteric circuit in caspase-1.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		R179 H237 Q283 C285
Binding residue
(residue number reindexed from 1)		R49 H107 Q153 C155
Enzymatic activity
Catalytic site (original residue number in PDB) P177 R178 H237 G238 C285 K286
Catalytic site (residue number reindexed from 1) P47 R48 H107 G108 C155 K156
Enzyme Commision number 3.4.22.36: caspase-1.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h51, PDBe:2h51, PDBj:2h51
PDBsum2h51
PubMed18590738
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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