BioLiP

Structure of PDB 2gws Chain A Binding Site BS01

Receptor Information

>2gws Chain A (length=327) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQE
ACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKT
AQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQT
VQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLL
DSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSE
FACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPG
RVLPTPTEKDVFRLLGLPYREPAERDW

Ligand information

>2gws Chain T (length=11) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cggcagcgcac

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	2gws Promiscuous mismatch extension by human DNA polymerase lambda.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	W274 T371 E465 E466 N467 Y505 R517 K521
Binding residue (residue number reindexed from 1)	W26 T123 E217 E218 N219 Y257 R269 K273

Enzymatic activity

Catalytic site (original residue number in PDB)	D427 D429 D490
Catalytic site (residue number reindexed from 1)	D179 D181 D242
Enzyme Commision number	2.7.7.7: DNA-directed DNA polymerase. 4.2.99.-

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

PDB	RCSB:2gws, PDBe:2gws, PDBj:2gws
PDBsum	2gws
PubMed	16807316
UniProt	Q9UGP5\|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)