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Structure of PDB 2cyb Chain A Binding Site BS01

Receptor Information >2cyb Chain A (length=319) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] DITEKLRLITRNAEEVVTEEELRQLIETKEKPRAYVGYEPSGEIHLGHMM TVQKLMDLQEAGFEIIVLLADIHAYLNEKGTFEEIAEVADYNKKVFIALG LDESRAKFVLGSEYQLSRDYVLDVLKMARITTLNRARRSMDEVSRRKEDP MVSQMIYPLMQALDIAHLGVDLAVGGIDQRKIHMLARENLPRLGYSSPVC LHTPILVGLDGQKMSSSKGNYISVRDPPEEVERKIRKAYCPAGVVEENPI LDIAKYHILPRFGKIVVERDAKFGGDVEYASFEELAEDFKSGQLHPLDLK IAVAKYLNMLLEDARKRLG

Ligand information Ligand ID TYR InChI InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 InChIKey OUYCCCASQSFEME-QMMMGPOBSA-N SMILES Software SMILES ACDLabs 10.04 O=C(O)C(N)Cc1ccc(O)cc1 OpenEye OEToolkits 1.5.0 c1cc(ccc1C[C@@H](C(=O)O)N)O OpenEye OEToolkits 1.5.0 c1cc(ccc1CC(C(=O)O)N)O CACTVS 3.341 N[CH](Cc1ccc(O)cc1)C(O)=O CACTVS 3.341 N[C@@H](Cc1ccc(O)cc1)C(O)=O Formula C9 H11 N O3 Name TYROSINE ChEMBL CHEMBL925 DrugBank DB00135 ZINC ZINC000000266964 PDB chain 2cyb Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2cyb Crystal Structures of Tyrosyl-tRNA Synthetases from Archaea Resolution 1.8 Å Binding residue (original residue number in PDB) Y36 G38 L69 A71 H74 Y158 Q162 D165 Q180 Binding residue (residue number reindexed from 1) Y35 G37 L68 A70 H73 Y157 Q161 D164 Q179 Annotation score 5

Enzymatic activity Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.

Gene Ontology Molecular Function GO:0000166 nucleotide binding GO:0004812 aminoacyl-tRNA ligase activity GO:0004831 tyrosine-tRNA ligase activity GO:0005524 ATP binding

	Biological Process
GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006437	tyrosyl-tRNA aminoacylation

	Cellular Component
GO:0005737	cytoplasm

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