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Structure of PDB 1xt4 Chain A Binding Site BS01

Receptor Information >1xt4 Chain A (length=295) Species: 5059 (Aspergillus flavus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] SAVKAARYGKDNVRVYKVHKDEKTGVQTVYEMTVCVLLEGEIETSYTKAD NSVIVATDSIKNTIYITAKQNPVTPPELFGSILGTHFIEKYNHIHAAHVN IVCHRWTRMDIDGKPHPHSFIRDSEEKRNVQVDVVEGKGIDIKSSLSGLT VLKSTNSQFWGFLRDEYTTLKETWDRILSTDVDATWQWKNFSGLQEVRSH VPKFDATWATAREVTLKTFAEDNSASVQATMYKMAEQILARQQLIETVEY SLPNKHYFEIDLSWHKGLQNTGKNAEVFAPQSDPNGLIKCTVGRS

Ligand information Ligand ID GUN InChI InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) InChIKey UYTPUPDQBNUYGX-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 NC1=Nc2[nH]cnc2C(=O)N1 ACDLabs 10.04 O=C1c2ncnc2N=C(N1)N OpenEye OEToolkits 1.5.0 c1[nH]c2c(n1)C(=O)NC(=N2)N Formula C5 H5 N5 O Name GUANINE ChEMBL CHEMBL219568 DrugBank DB02377 ZINC ZINC000000895129 PDB chain 1xt4 Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1xt4 Urate oxidase from Aspergillus flavus: new crystal-packing contacts in relation to the content of the active site. Resolution 2.01 Å Binding residue (original residue number in PDB) F159 R176 S226 V227 Q228 Binding residue (residue number reindexed from 1) F159 R176 S226 V227 Q228 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) K10 T57 R176 Q228 H256 Catalytic site (residue number reindexed from 1) K10 T57 R176 Q228 H256 Enzyme Commision number 1.7.3.3: factor independent urate hydroxylase.

Gene Ontology Molecular Function GO:0004846 urate oxidase activity GO:0016491 oxidoreductase activity

	Biological Process
GO:0006144	purine nucleobase metabolic process
GO:0006145	purine nucleobase catabolic process
GO:0019628	urate catabolic process

	Cellular Component
GO:0005777	peroxisome

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