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Structure of PDB 1uaa Chain A Binding Site BS01

Receptor Information >1uaa Chain A (length=636) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] RLNPGQQQAVEFVTGPCLVLAGAGSGKTRVITNKIAHLIRGCGYQARHIA AVTFTNKAAREMKERVGQTLGRKEARGLMISTFHTLGLDIIKREYAALGM KANFSLFDDTDQLALLKELTEGLIEDDKVLLQQLISTISNWKNDLKTPSQ AAASAIGERDRIFAHCYGLYDAHLKACNVLDFDDLILLPTLLLQANEEVR KRWQNKIRYLLVDEYQDTNTSQYELVKLLVGSRARFTVVGDDDQSIYSWR GARPQNLVLLSQDFPALKVIKLEQNYRSSGRILKAANILIANNPHVFEKR LFSELGYGAELKVLSANNEEHEAERVTGELIAHHFVNKTQYKDYAILYRG NHQSRVFEKFLMQNRIPYKISGGTSFFSRPEIKDLLAYLRVLTNPDDDSA FLRIVNTPKREIGPATLKKLGEWAMTRNKSMFTASFDMGLSQTLSGRGYE ALTRFTHWLAEIQRLAEREPIAAVRDLIHGMDYESWLYETSPSPKAAEMR MKNVNQLFSWMTEMLEGSELDEPMTLTQVVTRFTLRDMMEREEELDQVQL MTLHASKGLEFPYVYMVGMEEGFLPHQSSIDEDNIDEERRLAYVGITRAQ KELTFTLCKERRQYGELVRPEPSRFLLELPQDDLIW

Ligand information >1uaa Chain C (length=16) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] tttttttttttttttt

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1uaa Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP. Resolution 3.0 Å Binding residue (original residue number in PDB) T56 N57 H85 Q133 F183 W250 R251 R350 G351 N352 H353 R356 T556 H558 H580 S582 Binding residue (residue number reindexed from 1) T55 N56 H84 Q132 F182 W249 R250 R349 G350 N351 H352 R355 T552 H554 H576 S578

Enzymatic activity Catalytic site (original residue number in PDB) T29 D214 Q245 Catalytic site (residue number reindexed from 1) T28 D213 Q244 Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003678 DNA helicase activity GO:0003697 single-stranded DNA binding GO:0004386 helicase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016787 hydrolase activity GO:0016853 isomerase activity GO:0016887 ATP hydrolysis activity GO:0042803 protein homodimerization activity GO:0043138 3'-5' DNA helicase activity

	Biological Process
GO:0000725	recombinational repair
GO:0006260	DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006269	DNA replication, synthesis of primer
GO:0009314	response to radiation
GO:0031297	replication fork processing
GO:0044787	bacterial-type DNA replication

	Cellular Component
GO:0005829	cytosol
GO:0043600	cytoplasmic replisome
GO:1990077	primosome complex
GO:1990160	DnaB-DnaC-Rep-PriC complex

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