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Structure of PDB 1e4h Chain A Binding Site BS01

Receptor Information >1e4h Chain A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAA LLSPYSYSTTAVVTNP

Ligand information Ligand ID PBR InChI InChI=1S/C6HBr5O/c7-1-2(8)4(10)6(12)5(11)3(1)9/h12H InChIKey SVHOVVJFOWGYJO-UHFFFAOYSA-N SMILES Software SMILES OpenEye OEToolkits 1.5.0 c1(c(c(c(c(c1Br)Br)Br)Br)Br)O CACTVS 3.341 Oc1c(Br)c(Br)c(Br)c(Br)c1Br ACDLabs 10.04 Brc1c(O)c(Br)c(Br)c(Br)c1Br Formula C6 H Br5 O Name PENTABROMOPHENOL ChEMBL CHEMBL1235157 DrugBank DB03167 ZINC ZINC000001687157 PDB chain 1e4h Chain B Residue 999 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1e4h Structure of Human Transthyretin Complexed with Bromophenols : A New Mode of Binding Resolution 1.8 Å Binding residue (original residue number in PDB) K15 L17 A108 T119 Binding residue (residue number reindexed from 1) K6 L8 A99 T110 Annotation score 1 Binding affinity MOAD: Kd=3.9nM PDBbind-CN: -logKd/Ki=8.41,Kd=3.9nM

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0005179 hormone activity GO:0005515 protein binding GO:0042802 identical protein binding GO:0070324 thyroid hormone binding

	Biological Process
GO:0006144	purine nucleobase metabolic process
GO:0007165	signal transduction

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0035578	azurophil granule lumen
GO:0070062	extracellular exosome

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