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Structure of PDB 1drk Chain A Binding Site BS01

Receptor Information >1drk Chain A (length=271) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] KDTIALVVSTLNNPFFVSLKDGAQKEADKLGYNLVVLDSQNNPAKELANV QDLTVRGTKILLINPTDSDAVGNAVKMANQANIPVITLDRQATKGEVVSH IASDNVLGGKIAGDYIAKKAGEGAKVIELQGTAATSAARERGEGFQQAVA AHKFNVLASQPADFDRIKGLNVMQNLLTAHPDVQAVFAQNDEMALGALRA LQTAGKSDVMVVGFDGTPDGEKAVNDGKLAATIAQLPDQIGAKGVETADK VLKGEKVQAKYPVDLKLVVKQ

Ligand information Ligand ID RIP InChI InChI=1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3-,4-,5-/m1/s1 InChIKey SRBFZHDQGSBBOR-TXICZTDVSA-N SMILES Software SMILES OpenEye OEToolkits 1.5.0 C1C(C(C(C(O1)O)O)O)O OpenEye OEToolkits 1.5.0 C1[C@H]([C@H]([C@H]([C@@H](O1)O)O)O)O CACTVS 3.341 O[CH]1CO[CH](O)[CH](O)[CH]1O CACTVS 3.341 O[C@@H]1CO[C@@H](O)[C@H](O)[C@@H]1O ACDLabs 10.04 OC1C(O)COC(O)C1O Formula C5 H10 O5 Name beta-D-ribopyranose; beta-D-ribose; D-ribose; ribose; RIBOSE(PYRANOSE FORM) ChEMBL CHEMBL1159662 DrugBank DB04286 ZINC ZINC000004097544 PDB chain 1drk Chain A Residue 272 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1drk Probing protein-protein interactions. The ribose-binding protein in bacterial transport and chemotaxis. Resolution 2.0 Å Binding residue (original residue number in PDB) N13 F15 F16 D89 R90 R141 F164 N190 D215 Q235 Binding residue (residue number reindexed from 1) N13 F15 F16 D89 R90 R141 F164 N190 D215 Q235 Annotation score 4 Binding affinity MOAD: Kd=0.15uM PDBbind-CN: -logKd/Ki=6.82,Kd=0.15uM

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0005515 protein binding GO:0030246 carbohydrate binding GO:0048029 monosaccharide binding

	Biological Process
GO:0006935	chemotaxis
GO:0015752	D-ribose transmembrane transport
GO:0050918	positive chemotaxis

	Cellular Component
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

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