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BioLiP

Structure of PDB 1d9f Chain A Binding Site BS01

Receptor Information
>1d9f Chain A (length=601) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MISYDNYVTILDEETLKAWIAKLEKAPVFAFDTETDSLDNISANLVGLSF
AIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKY
DRGILANYGIELRGIAFDTMLESYILNSVAGRHDMDSLAERWLKHKTITF
EEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQKHKGPL
NVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEI
AGEEFNLSSTKQLQTILFEKQGIKPLKKTPSTSEEVLEELALDYPLPKVI
LEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQ
NIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAF
AEGKDIHRATAAEVFGLPLETVTSEQRRSAKAINFGLIYGMSAFGLARQL
NIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYLPD
IKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMI
MQVHDELVFEVHKDDVDAVAKQIHQLMENCTRLDVPLLVEVGSGENWDQA
H
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1d9f Structural origins of the exonuclease resistance of a zwitterionic RNA.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D355 E357 T358 L361 Q419 N420 K422 Y423 D424 M443 D457 M458 D459 I471 F473 Y497 D501 H660
Binding residue
(residue number reindexed from 1)		D32 E34 T35 L38 Q96 N97 K99 Y100 D101 M120 D134 M135 D136 I148 F150 Y174 D178 H333
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:1d9f, PDBe:1d9f, PDBj:1d9f
PDBsum1d9f
PubMed10588690
UniProtP00582|DPO1_ECOLI DNA polymerase I (Gene Name=polA)

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