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Structure of PDB 1a36 Chain A Binding Site BS01

Receptor Information >1a36 Chain A (length=544) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKML DHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTE ARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGR GNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLV SWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYRED WKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL HPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL FDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPA KILSYNRANRAVAILCNHQEKSMMNLQTKIDAKKEQLADARRDLKSAKAD AKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKL NFLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF

Ligand information >1a36 Chain B (length=22) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] aaaaagacttagaaaaattttt

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1a36 A model for the mechanism of human topoisomerase I. Resolution 2.8 Å Binding residue (original residue number in PDB) H266 R362 R364 V410 T411 W412 I424 Y426 M428 K436 K439 K443 R488 K532 D533 K587 R590 H632 Q633 K650 T718 N722 F723 Binding residue (residue number reindexed from 1) H52 R148 R150 V196 T197 W198 I210 Y212 M214 K222 K225 K229 R274 K318 D319 K373 R376 H418 Q419 K429 T497 N501 F502

Enzymatic activity Enzyme Commision number 5.6.2.1: DNA topoisomerase.

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity

	Biological Process
GO:0006265	DNA topological change

	Cellular Component
GO:0005694	chromosome

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